題目: A versatile model system for studying non-covalent interactions of aromatic surfaces
主講人: Ken D. Shimizu
主持人: 張亞剛 教授
時 間: 2019年10月22日（周二），上午10點
地 點: 清水河校區研究院大樓304A
Ken D. Shimizu 教授是美國University of South Carolina 化學與生物化學系主任，1995年博士畢業于美國麻省理工學院U2电竞体育，獲得 SC ACS Chemist of the Year award, Mortar Board Excellence in Teaching Award 等獎十多項U2电竞体育U2电竞体育。主要研究領域為：超分子化學、分子識別與分子印跡U2电竞体育、物理有機化學和材料化學。
Non-covalent interactions of aromatic surfaces are important to the function of many synthetic and biological systems. Yet, the fundamental origins and stability trends of these weak interactions are still a subject of considerable study and debate. One reason is the lack of accurate and comprehensive experimental data. To address this problem, we developed a small molecule model system that can form and accurately measure the strength of intramolecular interactions of aromatic surfaces. Due to a central N-arylimide single bond with restricted rotation, the rigid bicyclic framework is in equilibrium between folded and unfolded confirmations, which can and cannot form the intramolecular noncovalent interaction. Thus, measurement of the folded/unfolded ratio by H NMR integration provides a measure of the interaction of interest. Due to the synthetic versatility and ease of preparation, we have applied this model system to study a range of noncovalent interactions of aromatic surfaces including: face-to-face π-stacking, dispersion, OH-π, fluorine-π, heterocyclic π-stacking, and Ag-π.